stilbœstrol Pharm.
(stɪlˈbiːstrɒl, -ˈbɛstrɒl)
Also (U.S.) stilbestrol.
[f. stilbene + œstrus + -ol.]
† a. A synthetic derivative, HOC6H4·CH:CH·C6H4OH, of stilbene having slight œstrogenic properties; also, any derivative of this. Obs.
| 1938 E. C. Dodds et al. in Nature 5 Feb. 248/1 In view of the fact that 4:4{p}-dihydroxystilbene is the mother substance of a series of œstrogenic agents, we suggest that it may be termed stillbœstrol. 1938 Nature 2 July 34/1 (heading) Oestrogenic activity of alkylated stilbœstrols. 1943 Vitamins & Hormones III. 233 This substance..is known as diethylstilbestrol, the term stilbestrol being used for the parent substance. |
b. A powerful synthetic nonsteroidal œstrogen, HOC6H4·C(C2H5):C(C2H5)·C6H4OH, used, often in the form of its dipropionate, in hormone therapy, as a postcoital contraceptive, and as a growth-promoting agent esp. in cattle and sheep; = diethylstilbœstrol s.v. diethyl 2.
| 1939 Lancet 7 Oct. 788/1 Oral administration of the synthetic œstrogen, stilbœstrol, will inhibit implantation of the ovum in the rat and rabbit. 1943 Vitamins & Hormones III. 233 In Great Britain the substance is commonly known as stilbestrol, although it should, of course, be referred to as diethylstilbestrol. 1957 [œstrogenic a.]. 1959 Times 29 Apr. 12/6 Farmers were warned yesterday that breeding stock should not be implanted with stilbœstrol. 1976 Smythies & Corbett Psychiatry xi. 209 Stilboestrol given to men reduces libido. |