Does the red blood cell in frogs undergo amitosis? It is a notion particularly popular among Chinese high school Biology textbooks, that the red blood cells in frogs can undergo amitosis (not mitosis), a claim which I have not been able to find reference. A search on Pubmed led me to this article, which states: > The nucleus of the frog erythrocyte is not a regular ellipsoid; ... a single nuclear invagination located at one end of the long axis is frequently seen in the phase microscope. However I have also been unable to find more recent researches on the nature of this observation, and whether it is related to amitosis. Can you help me find some?

Unlike mammalian blood cells, blood cells in Amphibia are nucleated (as the paper in your link explains) and can perform cell division (here is an old paper from _Acta Haematologica_ , 1954: <

Your question is: is this division a regular mitosis or the so called _amitosis_? According to Barni et al., 1995, amphibian blood cells can perform amitotic cell division:

> The proliferation of haemopoietic cells, detected by the anti-BrdU labelling index, was accompanied by absence of mitotic cell division and the appearance of cells showing features of amitosis (e.g. nuclear constrictions with bundles of electron-dense chromatin)

Source: Barni, S., Fraschini, A., Prosperi, E., Vaccaronel, R. and Bernini, F. (1995) ‘Possible occurrence of amitotic cell division during haemopoiesis in the Urodeles’, Comparative Haematology International, 5(3), pp. 183–188. doi: 10.1007/bf00368042.