is the most commonly used phrase used to tell someone to calm down. However, there are several ways to simply state that someone is annoyed or overly upset. Eg. , {}.
If someone is getting annoyed over trivial matters you can use the word to describe the matter.
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> He is angry over trivial matters.
There may be an even closer translation, but this one is pretty close.
You might be able to extend that to requests.
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> Don't get angry over little things.
But this might not be very natural. Usually if someone were getting uptight over little things I would probably tell them (if they were close) something like:
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> It's nothing more than a trivial thing. Calm down.
or
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> It's nothing. Calm yourself.