First, you should note that reflexive and irreflexive aren't negations of each other; a relation can have one of the two properties, or neither of the properties, though it can't have both (unless you allow relations on the empty set). So you really have to prove two separate statements.
Assuming you're familiar with logical negation, then the negation of being reflexive is $\exists a\in A:(a,a)\
otin R$ and the negation of being irreflexive is $\exists a\in A: (a,a)\in R$. These are what you have to prove to show not being reflexive and not being irreflexive respectively.