Can different kinds of dogs mate? This was inspired by a show in which two different kinds of dogs, who were neighbors, "dated," in order to bring their human neighbors together. This is a theme seen in Disney's "101 Dalmations" or "The Lady and the Tramp." Can dogs of similar sizes, say Rotweilers or pitbulls actually interbreed? Can any of them mate with say, wolves? And under what circumances? (I am "encouraged" by the fact that horses and donkeys can produce mules, and lions and tigers can produce "liger" or "tigons." Also of note is that dogs are of the same species as wolves, and "domestic dogs" are actually a subspecies.)

Yes, the vast majority of dogs out there are not pure bred. They are therefore a cross between two breeds. Consider cockapoos for example. The offsprings of a Cocker Spaniel and a poodle is called a cockapoo.