Odd as it may sound, not every subset of $\Bbb{R}^3$ that is homeomorphic to a 2-sphere is the boundary of something homeomorphic to a 3-ball. One famous example of this is the Alexander horned sphere. In the terms of that article, the solid Alexander horned sphere (the exterior of the Alexander horned sphere, together with the point at infinity) is a particular crumpled cube that is not a 3-ball.