Artificial intelligent assistant

What is the difference between a fixed substitution and a single nucleotide polymorphism (SNP)? I recently read a report that stated "We found 430 **fixed substitutions** […], with an additional 34 **single nucleotide polymorphisms** (SNPs) fixed within individual patients." What is the difference between both terms?

If you look into a certain population, you will find mutations (for example SNPs) in some ratio with the wild-type allele. When a mutation reaches fixation, it will be the only allele, reaching 100% penetrance in this population. See here for more information.

In the context given I would interpret it in the way that a total of 464 SNPs were found, 430 of these were in fixation (so can only be discovered when comparing them to another population) and 34 SNPs which haven't reached fixation and thus cannot be found in all members of the population.

xcX3v84RxoQ-4GxG32940ukFUIEgYdPy c105d99f1f64750cc3f273ab73aa909a