Try:
$ echo "IBM, Inc.:APP-VM-Core:4.4.2.0:04," | sed '/^ *IBM/s/,//'
IBM Inc.:APP-VM-Core:4.4.2.0:04,
or:
$ echo "IBM, Inc.:APP-VM-Core:4.4.2.0:04," | sed 's/^\( *IBM\),/\1/'
IBM Inc.:APP-VM-Core:4.4.2.0:04,
Try:
$ echo "IBM, Inc.:APP-VM-Core:4.4.2.0:04," | sed '/^ *IBM/s/,//'
IBM Inc.:APP-VM-Core:4.4.2.0:04,
or:
$ echo "IBM, Inc.:APP-VM-Core:4.4.2.0:04," | sed 's/^\( *IBM\),/\1/'
IBM Inc.:APP-VM-Core:4.4.2.0:04,