Think about how many crossings you can get if you have a quadrilateral. I would say that you can have at most one crossing, but that means your knot is trivial and therefore there are no knotted quadrilaterals.
Now a similar argument works for pentagons.
I do not think that there are only unknotted hexagons as you said since the trefoil knot is for example given by a hexagon. Actually, that should be the only non-trivial one since the trefoil knot and its mirror image are equivalent by your definition of equivalence.
For heptagons the only non-trivial knot that arises should be the unique knot with crossing number $4$, the figure eight knot.
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