Signaling pathways with Receptor Tyrosine Kinase clarification This question is regarding signaling pathways with RTKs, Receptor Tyrosine Kinase. The picture posted has one thing wrong with it and I am supposed to figure out what that is. ![enter image description here]( What I have come up with so far is that the Ras protein shown that goes on to activate RAF, has GDP attached to it. This cannot be true from what I understand, as Ras must have GTP bound to it in order for Ras to stay in it's closed conformation. The closed conformation is what activates the rest of the signals. I am wondering if I am correct in my assumption, or if there is something else in the diagram I am missing.

The active form of Ras should definitely be bound to GTP, to activate Raf. I don't see anything else wrong with the diagram. For reference, here is another useful diagram the pathway from Nature.