Make the `Insert` key send a different keysym (the symbolic name of the key that determines what key applications think it is), for example `F25`.
xmodmap -e "keycode 106 = F25"
Configure mc to recognize `f25` as a binding for the `Mark` command: copy `/etc/mc.keymap` (or wherever the keymap you're using is located) to `~/.mc/mc.keymap` and change the line `Mark = insert; ctrl-t` to `Mark = insert; f25; ctrl-t`.