[]{} []{}
It refers to the head of each []{}(Ministry) of the Japanese Government. The U.S. counterpart of our would be "Department". is the "official" word and is used like a nickname as looks and sounds pretty heavy for everyday use.
To take []{}(Ministry of Education, Culture, Sports, Science and Technology) as an example, its head is officially named []{} but since that is long, it is very often shortened to []{}.
As for the Prime Minister, you will see/hear (therefore need to know) all of []{}[]{}[]{} and []{} in the order of formality. , with or without a family name in front, would be like "Mr. President" in the U.S.
Finally, unless you are planning to be like Donald Keene, you do not need to know the word . It has much more to do with old China than old or current Japan.