No, everything is possible.
Note that expanding or simplifying one of your fractions won't change which of the the fractions is larger or smaller (since it doesn't change the value of the fraction at all), but it can change the sign of $c$, since only one of the two terms will change.
Example: $$ \frac{2}{1} > \frac 11\\\ c = 2\cdot 1 - 1\cdot 1 = 1>0 $$ but $$ \frac21 > \frac 22\\\ c = 2\cdot 1 - 2\cdot 2 = -2 < 0 $$