Growth Hormone and diabetes Growth hormone and insulin like growth factors are diabetogenic, so I assume that people with high growth hormone (say due to pituitary tumor) may be at high risk for diabetes. Has any correlation been established between these two? I know that diabetes is a multifactorial disorder and so only a correlation may be established.

Yes:

> That GH has an effect on glycaemic control is most evident from the abnormal glucose tolerance seen in acromegalics...

`acromegaly` is defined as `abnormal growth of the hands, feet, and face, caused by overproduction of growth hormone by the pituitary gland.`

Such an effect has been known for decades, which makes sense given how interrelated the axes are. Although I think the best evidence is the fact that the side effects of growth hormone therapy says that `Some patients have developed diabetes mellitus...`