Directly translated into awk:
awk -F'\t' '!($5 ~ /i_r/ || $5 ~ /u_v/ || $6 == 1) { print; }' input
1. Set the field separator to tab `\t`
2. If the following conditions are _not_ true `!( ... )`
3. Condition one: field 5 contains `i_r`, or
4. Condition two: field 5 contains `u_v`, or
5. Condition three: field 6 is `1`, then
6. `print` the line
Lines that match any of the conditions will not be printed ("deleted").
Sample output:
#CHR POS REF ALT EFC GOM
9 600 T G d_i(XXXXXX);f_v(XXXXXXXX) -