Artificial intelligent assistant

Diffusion of FAD+ Why is NAD+ free to diffuse within the mitochondrion whereas FAD+ is not ? What biochemical properties cause this difference ?

As explained at the Wikipedia page for succinate dehydrogenase the FAD is covalently attached to one of the subunits of the protein. It is the first carrier in a short **intramolecular** redox chain involving Fe-S clusters, and possibly a haem, before the electrons derived from succinate are passed on to ubiquinone and on down the respiratory chain.

As you say, this contrasts with NAD which is a diffusible coenzyme.

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