### solution 1:
awk '{print $1 " " $2 NR " " $3 " " $4 " " $5 " " $6 NR}' yourfile.txt
![solution 1 screenshot](
### solution 2:
awk '{$2 = $2 NR; $6=$6 NR; print }' yourfile.txt
![solution2 screenshot](
### sequencer for each replace
in case if you prefer sequencing each replacement, a perl version
perl -pe 's/enhancer_/$& .++$n/ge' yourfile.txt
![perl solution with sequence](