While a conventional nipple wrench turns the nipple by the exposed flat surfaces that protrude from the rim, a nipple driver turns the nipple from the inside of the wheel.To replace a single spoke you can use a spoke wrench or a driver. Some people find it easier starting the nipple onto the spoke with a driver than with a wrench. If you were truing a wheel the wrench is easier as the tire and tube need not be removed. If you remove the tire, tube and the rim strip you will see the head of the nipple. If you are building a wheel it is more efficient to use the driver to start each nipple on to the spoke. To replace a single spoke you can use a spoke wrench or a driver.