Genomic instability of cancer cells in h&e image Is there are any books or papers on the topic of visual differences(analyzing H&E microscopy) of high grade cancer cells vs low grade cancer cells vs non-cancer cells? In particular, I am trying to measure how much of genome was altered by analyzing images.

Histologic diagnosis of tumors is made using the so-called WHO blue books.

Different tumors show different patterns of cellular and tissual aberrations.

On h&e karyorrexis and pyknosis are examples histological markers of nuclear aberration.

A recent paper reviews the salient visual and subvisual morphological changes of cancer nuclei and their possible cause or _etiology_ and significance.