Let us suppose we decide to use the sample space of $8^5$ that you used for the first part. Then for the numerator we want to find the number of choices in which exactly $4$ venues are chosen.
Which $4$? They can be chosen in $\binom{8}{4}$ ways. For every choice of $4$ venues, there are $\binom{4}{1}$ ways to choose the one that will be attended by $2$ scientists. Which $2$ scientists go to this popular venue? They can be chosen in $\binom{5}{2}$ ways. And once this is done, the remaining $3$ scientists can be distributed among the $3$ remaining chosen venues in $3!$ ways, for a total of $\binom{8}{4}\binom{4}{1}\binom{5}{2}3!$.
Or else we could choose the popular venue first, $\binom{8}{1}$ ways, and the scientists that go there, $\binom{5}{2}$ ways. That leaves $7$ venues, of which we choose $3$, and then multiply by $3!$. Same number.