State Highway 6 runs from the Red River, the Texas–Oklahoma boundary, to northwest of Galveston. In Sugar Land and Missouri City, it is known as Alvin-Sugarland Road and runs perpendicular to I-69/US 59. In the Houston area, it runs north to FM 1960, then northwest along US Highway 290 to Hempstead, and south to Westheimer Road and Addicks.