Questions like these are usually best resolved by looking in a (monolingual) dictionary (and/or on a Wikipedia disambiguation page).
For example, has two entries for :
> ****
>
> ①
>
> ② {} 1
>
> * * *
>
> ****
>
>
While the second entry is about the Tokyo district _Meguro_ , the first entry lists two meanings — one being a particular bird species, a bonin white-eye, the other being a name for a small tuna.
lists yet another meaning, namely that can be used as a different name for "pupil", which is usually _kurome_.
The etymologies of "tuna" (=?) or the district _Meguro_ are not 100% clear, but in the other cases it is quite clear that it is used for the literal meanings of "eye" and "black".
Using with other meanings (such as "guilty vision") which are not listed in a reasonably complete dictionary will most likely just result in confusion.