**Artificial selection leading to new species - Domestication**
As you talk about dogs in your intro, let's consider them.
You will fail to breed a great dane and chihuahua for obvious mechanical reasons. You will also fail to breed a chihuahua with a wolf. So, yes artificial selection have lead to reproductive isolation.
**Artificial selection leading to new species - lab experiment**
Artificial selection have also lead to reproductive isolation in non-domesticated species. See for example the post Have we ever observed two drosophila lineages that evolved reproductive isolation in labs?
**Concept of species**
As a side note... Above, I consider the so-called 'biological species concept'. For a discussion on the definition of species, please have a look at this post.