CDRs and antigen-binding sites Are complementarity determining regions (CDRs) not the same thing as antigen-binding sites? If not, what is the difference? An old exam question states: > "Clarify how CDRs are related to the antigen binding sites" To answer this I would simply say that CDRs provide a binding surface that is complementary to that of the antigen. Is that what is meant by the question or am I missing something? All help is appreciated!

Each antigen binding site (also known as paratope) is made up of six complementarity-determining regions (CDRs) - three from each of the light and heavy chains.