How to identify a coiled coil from the amino acid sequence? I was wondering, when we have an amino acid sequence, is it enough to check whether the positions a-d correspond to hydrophobic amino acids in order to say whether it can form a coiled coil structure? Or would we need to make sure the other positions are not hydrophobic too? All help greatly appreciated.

> The heptad repeat, denoted [abcdefg]n, typically has hydrophobic residues at **a** and **d** , and polar/charged residues at **e** and **g**.

From here.

There is a prediction tool with useful images here.