You don't like the power of something complicated (in particular, you do _not_ want to have to expand the power). So you want the inside of the power to be $u$. (This is a good thing to try in other problems; depending on the setup, it may or may not work.) Then $u'=6x^5-6x$. You pretty much have this already, except for the $6$, but you can bring in constant multiples as you wish, provided you balance them. Specifically, you can write $\int (x^6-3x^2) (x^5-x) dx = \frac{1}{6} \int (x^6-3x^2) (6x^5-6x) dx$. Then with $u=(x^6-3x^2)$, your integral is $\frac{1}{6} \int u^4 du$.