How does ANF increase GFR? ANF as we know reduce the Na+ uptake and K+ removal in the distal tubules and it also functions as a Vasodialator (?) But again it says that ANF increases the Glomerular filtrate ? But if it is acting has a Vasoldialator ( _ie, antagonistic to Vasopressin_ ) how is it increasing the GFR ? Shouldnt it lower the GFR ? * * * ANF - Atrial Natriuretic Factor also called Atrial Natriuretic Peptide GFR - Glomerular Filtration Rate

ANF (Atrial Natriuretic Factor more commonly known as ANP - atrial natriuretic peptide) squeezes (vasoconstricts) the efferent arteriole. This means the pressure in the glomerulus is higher (like if you squeeze the end of a hose) and so more fluid is squeezed out i.e. the glomerular filtration rate (GFR) is higher. It also dilates the afferent which means more fluid is going in, further increasing GFR ( _Marin-Grez et al._ )

!Glomerulus