You would be better served by a shell function:
doit () {
local dir
case $PWD/ in
/home/alpha/*) dir=alpha ;;
/home/beta/*) dir=beta ;;
/home/gamma/*) dir=gamma ;;
*) echo 'Not standing in the correct directory' >&2
return 1
esac
python "/home/$dir/src/doit.py" --clean "$@"
}
This would set the variable `dir` to the string `alpha`, `beta` or `gamma` depending on the current working directory, or complain that you're in the wrong directory tree if the current directory is elsewhere.
It then runs the Python script, utilizing the `$dir` value, with the `--clean` option and adds whatever other arguments that you've passed to the function.
You would add this shell function's definition to wherever you ordinarily add aliases.