A classic example is juglone from Black Walnut tree roots. This review from 1973 discusses juglone and allelopathy, inhibiting growth of other trees. This 1961 paper describes juglone's effects as able to sedate or at depress movement of _Daphnia magna_ , leopard frogs, perch, catfish, goldfish, mice, rats and rabbits. That led to work testing juglone on cancer cells.