I am guessing that you mean you wish to prove that $G/Z(G) \cong \mathbb{Z}_2 \times \mathbb{Z}_2$, because otherwise your statement implies that $|G| = 16$.
Assuming this, begin by showing that if $G/Z(G)$ is cyclic, then the group $G$ must be abelian. Hence, since there is only one non-cyclic group of order $4$, the result follows immediately.