Yes, it is true that every natural number $n$ can be written in one and only one way as $2^mq$ where $q$ is an odd number. Let $2^m$ be the greatest divisor of $n$ which is a power of $2$ (note that $1$ is a power of $2$, since $1=2^0$). Now let $q=\frac n{2^m}$. It is clear that $q$ is odd; otherwise, $2^m$ wouldn't be the greatest power of $2$ that divides $n$. Finally, it is clear that $m$ is unique, since it was the defined as the greatest exponent of $2$ for which $2^m\mid n$.