Yes, represents screams of higher tone, and is clearly feminine or childlike. is usually . Gay characters often say in manga, too.
, on the other hand, is not necessarily masculine. When female characters use , it's usually bolder, more urgent, or stronger than (for example, a dying scream).
In general, voiced consonants tend to be used more often to represent larger, rougher and/or lower-pitched sounds. is the sound of vulgar laughter of middle-aged men, whereas sounds young/cute/feminine. The same is generally true for onomatopoeia pairs like , , .