Type I and Type II Topoisomerases Type I topoisomerase changes the linking number by ±1 by changing the number of **twist** present in a DNA, breaking only one strand. Type II topoisomerase changes the linking number by ±2 by changing the **configuration of the writhe** ,breaking both the strands. Am I right?

The speculations are right.

Topoisomerase I changes the linking number by changing the number of twists and Topoisomerase II changes the linking the number by changing the writhe of DNA.

Confirmed by a college professor.