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Pyruvate oxidation - where did the hydrogen come from? ![enter image description here]( (source: resource12ubio at sites.google.com) As shown in the diagram above, NAD+ is reduced and becomes NADH by gaining two electrons Now, where did the hydrogen come from? In the diagram, pyruvate has 3 hydrogen, but it still has 3 hydrogen in acetyl CoA.

The Wikepedia page has a really good diagram of the reactions involved. The Pyruvate Dehydrogenase Complex facilitates the removal of CO2, and the addition of two hydrogen atoms to the overall reaction come from the FADH2/FAD molecule.

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