$\underline{Method\;\; avoiding\;\; casework:}$
Taking the symbols to be $AABBCD$ and straightening the $\Bbb{E}$ pattern for simplicity,
permute the symbols and put them in $5$ boxes, e.g. one permutation could read $\boxed{AB-}\boxed{D}\boxed{B--}\boxed{C}\boxed{-A-}$
There are $\frac{6!}{2!2!} = 180$ permutations of symbols,
$3\binom32 = 9$ ways of choosing box for two symbols, and placing them,
and $3\cdot3 = 9$ ways for placing a symbol in the other two "triple" boxes
Putting it all together, we get a total of $180\cdot81$ ways