It depends what you mean by "demi-god".
They are of somewhat divine origin, by most understandings of "sons of God" (ancient Hebrew sources identify them with angels of some description). They were men of great renown. That much is in common with the Greek tradition of heroes of divine heritage.
However, the Greek heroes (not all of whom were demi-gods in the sense of divine parentage) are the focus of many key stories of myth and actually a focus of religious practice in their cultures - the hero cults. The same cannot be said of the Nephilim in Christianity or Judaism.