The products that are adjacent on the Karnaugh map are $(100,110)$ and $(001,011)$. In the first pair, $x$ and $z$ are set, but $y$ can take either value. So, the pair of products $xy'z' + xyz'$ can be "factored" into $xz'$.
Similarly, the other pair can be simplified into $x'z$.
So, we find $$ F(x,y,z) = x'z + xz' $$ (which is to say, $x$ XOR $z$).