Assuming the people are distinguishable, as most people are...
(a) There are $\binom{80}{15}$ ways to choose the people which go in the first wagon, then $4^{65}$ ways to distribute the others (each person can go in one of four wagons).
(b) Use inclusion exclusion. For each wagon, count the number of ways where that particular wagon has $15$ people. Then subtract the doubly counted arrangements where two particular wagons have $15$ people, then add back in the triply counted ones, etc.