Why Hfr cells are called high frequency recombination cells? I understand that Hfr cells are formed when fragment of bacterial plasmid integrates itself in another bacteria's (host) genome through homologous recombination but my question is why do we call these cells as "high frequency recombination cells". Where is the term high frequency coming from?

According to Luca Cavalli-Sforza, the scientist who coined the acronym _Hfr_ :

> Recombination as observed at the beginning had a very **low** frequency. It stopped being rare when I found a mutant strain which I called Hfr for “ **high** frequency of recombination.” I found it accidentally in 1949 while I was selecting mutations resistant to nitrogen mustard and radiation. The first two resistant mutants, which had undergone a rather heavy treatment in the process of selecting for resistance to nitrogen mustard, proved to be exceptional in their mating behavior. One was Hfr and it showed immediately its remarkable mating ability, which was higher than that of normal crosses by a factor of 1000 or more. I repeated the experiment two more times before believing it. The other mutation, as I later proved, was an F- (self-sterile) mutation of an F+ (fertile) strain. (emphases mine)

Source: Forty Years Ago in GENETICS: The Unorthodox Mating Behavior of Bacteria