use of ときては in this sentence context is about drugging someone up to get them to more lively again for sexual purposes > **** > > before long her responses became dull, we used the drug, thinking that it would get her back to form....... "" are recklessly fired two days into the future, on top of that, because the "" and simply collected , a feeling of excrement is impending. Honestly, i have no idea what this saying in the 2nd part, there some strange euphemism here? i've read this > is this appropriate to apply to this sentence?

`noun + ` is an exclamatory and emphatic set phrase which is like "you know what", "on top of that", "when it comes to ...", etc. See: What does mean?

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Likewise, this somewhat emphasizes the long noun phrase, .

This rougly means "soon after (realizing) ", "once ". is an idiomatic set phrase meaning "completely wrong direction", "in a totally unexpected way", etc. I'm not sure what this refers to, but it may be related to this sense.