> Can I use without sounding like a weirdo ?
Yes.
> Is there a difference between the two ?
Yes. A question with is usually asking about a reason, or following up on a piece of information. For example, means "are you studying?", and might have undertones of "is _that_ why (e.g.) you can't come out tonight?", whereas is a straightforward yes/no question. Compare ("I am studying") with ("(it's because) I am studying").