Is prescription fish oil better than over-the-counter fish oil? The possible health benefits of fish oil (primarily from its omega-3 content) have made it a popular supplement. There are a lot of over-the-counter fish oil supplements (google fish oil) on the market and one (that I know of) that is only available by prescription. Is there any scientific evidence that prescription fish oil is better (more effective, safer, other) than over-the-counter fish oil ?

Better in what way?

Better because it's cheaper? Better because it works faster? Better because it kills less puppies?

Some argue that you should take omega 3, 6 & 9 instead of Fish oil.

The fact that a product is (or isn't) on prescription (in the US) only means that it has gone through FDA approval.

As for which is better, I'd try both for a few weeks. Ask you better half if they notice an improvement!