alienation
/ˌeɪlɪəˈneɪʃn; ˌelɪən`eʃən/ n[U]
~ (from sb/sth) alienating or being alienated; estrangement 疏远; 离间
His criminal activities led to complete alienation from his family. 他的犯罪活动导致了他与家庭完全隔绝.
Mental illness can create a sense of alienation from the real world. 精神病能产生一种与现实世界脱离的感觉.