estrange
/ɪˈstreɪndʒ; ɪ`strendʒ/ v[esp passive 尤用於被动语态
Tn, Tn.pr]
~ sb (from sb) cause (sb formerly loving or friendly) to become unfriendly to sb 使（某人）疏远某人; 离间
He's estranged from his wife, ie no longer living with her. 他和妻子分居了.
They are estranged. 他们疏远了.