despite
/dɪˈspaɪt; dɪ`spaɪt/ prep
without being affected by (the factors mentioned) 尽管; 不管; 不顾
They had a wonderful holiday, despite the bad weather. 尽管天气不好, 他们的假日还是过得极为愉快.
Despite wanting to see him again, she refused to reply to his letters. 她尽管很想再见到他, 但却不愿给他回信.
Despite what others say, I think he's a very nice chap. 不管别人怎麽说, 我仍认为他这个人很好. Cf 参看 in spite of (spite).